This medication may contain sugar and/or Liquor. Caution is advised For those who have diabetic issues, alcohol dependence, or liver ailment. Request your health practitioner or pharmacist about utilizing this product or service safely.
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Codeine: A study in rats and rabbits reported no teratogenic outcome of codeine administered over the duration of organogenesis in doses starting from five to 120 mg/kg. Inside the rat, doses within the 120-mg/kg degree, during the poisonous vary for the adult animal, have been associated with an increase in embryo resorption at the time of implantation.
The narcotic antagonist, naloxone hydrochloride, could be administered when sizeable respiratory depression takes place with promethazine and codeine; any depressant results of promethazine usually are not reversed with naloxone. Diazepam might be utilised to regulate convulsions. Avoid analeptics, which can result in convulsions. Acidosis and electrolyte losses must be corrected. An increase in temperature or pulmonary complications may perhaps sign the necessity for institution of antibiotic therapy.
This medication can dry up and thicken mucus inside your lungs, making it harder to breathe and apparent your lungs. To aid protect against this outcome, consume a good amount of fluids Until or else directed by your health care provider.
This solution might comprise inactive elements, which could bring about allergic reactions or other issues. Check with your pharmacist for more aspects.
Promethazine with Codeine Syrup, a clear purple syrup with odor of grape menthol, incorporates promethazine hydrochloride 6.
Your mouth may perhaps get dry. Chewing sugarless gum or sucking difficult sweet and ingesting an abundance of h2o could aid. Get hold of your treatment group if the challenge doesn't go away or is extreme.
Promethazine may decrease seizure threshold. It should be employed with caution in individuals with seizure Conditions or in individuals who're using concomitant prescription drugs, including narcotics or nearby anesthetics, which can also have an affect on seizure threshold.
If this SPL includes inactivated NDCs mentioned with the FDA initiated compliance action, They are going to be specified as such.
It is soluble in water and freely soluble in Liquor. The molecular pounds is 320.88. Its molecular system is C17H20N2S•HCl, and it's the following chemical framework.
Postmarketing conditions of respiratory despair, which include fatalities are actually reported with usage of promethazine in pediatric clients.
Existence-threatening respiratory despair and Dying have transpired in young children who obtained codeine. Codeine is matter to variability in metabolism dependent on CYP2D6 genotype (explained down below), which can cause a heightened exposure into the Energetic metabolite morphine. Based mostly on put up-marketing and advertising reviews, youngsters youthful than 12 several years old look like more prone to the respiratory depressant results of codeine, specially Promethazine codeine syrup if you will discover hazard things for respiratory despair.
When medical professionals prescribe codeine-containing medicine, they ought to pick the least expensive successful dose to the shortest time period and may advise their patients about these hazards plus the indications of morphine overdose (see PRECAUTIONS - Nursing Moms).